TBIO-08. BASE-RESOLUTION METHYLOMES OF GLIOMAS BEARING HISTONE H3.3 MUTATIONS REVEAL A G34 MUTANT-SPECIFIC SIGNATURE SHARED WITH BONE TUMORS

BACKGROUND: Two recurrent mutations, K27M and G34R/V, in H3F3A, encoding non-canonical histone H3.3, are reported in pediatric and young adult gliomas, whereas G34W mutation was prevalent in bone tumors. In contrast to K27 mutation, it remains elusive how G34 mutations affect the epigenome. Here we...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Sangatsuda, Yuhei, Miura, Fumihito, Araki, Hiromitsu, Mizuguchi, Masahiro, Hata, Nobuhiro, Kuga, Daisuke, Hatae, Ryusuke, Akagi, Yojiro, Amemiya, Takeo, Fujioka, Yutaka, Arai, Yasuhito, Shibata, Tatsuhiro, Yoshimoto, Koji, Ito, Takashi, Iihara, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Biology (not fitting a specific disease category)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715604/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.836
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