MODL-25. REPLICATION REPAIR DEFICIENT MOUSE MODELS PROVIDE INSIGHT ON HYPERMUTANT BRAIN TUMOURS, MECHANISMS OF IMMUNE EVASION, AND COMBINATORIAL IMMUNOTHERAPY

Replication repair deficiency (RRD) is the leading cause of hypermutant brain tumours in children. RRD is caused by defects in one of four mismatch repair (MMR) genes and mutations in POLE or POLD1. Such tumours are resistant to common therapeutic agents and animal models are needed to study RRD in...

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Publicado en:Neuro Oncol
Autores principales: Galati, Melissa, Li, Li, Sudhaman, Sumedha, Lipman, Tatiana, Stengs, Lucie, Elshaer, Dana, Bridge, Taylor, Semenova, Dar’ya, Edwards, Melissa, Hodel, Karl, Forster, Victoria J, Nunes, Nuno M, Martin, Alberto, Bouffet, Eric, Pursell, Zachary, Hawkins, Cynthia, Tabori, Uri
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715596/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.598
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