DIPG-70. DISORDERED DNA METHYLATION IN DIPG UNDERLIES PHENOTYPIC PLASTICITY

Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a dismal prognosis and no effective treatment. Recent studies point to a critical role for epigenetic dysregulation in this disease. Nearly 80% of DIPGs harbor mutations in histone H3 encoding replacement of lysine 27 with m...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Koldobskiy, Michael, Tetens, Ashley, Martin, Allison, Eberhart, Charles, Raabe, Eric, Goutsias, John, Feinberg, Andrew
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715591/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.112
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