DIPG-74. DNA METHYLATION STOCHASTICITY IN DIPG

Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a dismal prognosis and no effective treatment. Recent studies point to a critical role for epigenetic dysregulation in this disease. Nearly 80% of DIPGs harbor mutations in histone H3 encoding replacement of lysine 27 with m...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Koldobskiy, Michael, Jenkinson, Garrett, Pujadas, Elisabet, Martin, Allison, Eberhart, Charles, Goutsias, John, Raabe, Eric, Feinberg, Andrew
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011891/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.166
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