EPCT-12. PNOC015: PHASE 1 STUDY OF MTX110 (AQUEOUS PANOBINOSTAT) DELIVERED BY CONVECTION ENHANCED DELIVERY (CED) IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) PREVIOUSLY TREATED WITH RADIATION THERAPY

OBJECTIVE: To determine safety and distribution of MTX110 delivered by CED in newly diagnosed DIPG patients. METHODS: DIPG patients (3–21 years) were enrolled after radiation. CED of MTX110 combined with gadoteridol was completed based on dose levels (DL) (30–90 µM with volumes ranging from 3 cc (si...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Mueller, Sabine, Kline, Cassie, Villanueva-Meyer, Javier, Hoffman, Carly, Raber, Shannon, Bonner, Erin, Nazarian, Javad, Lundy, Shannon, Molinaro, Annette M, Prados, Michael, Filbin, Mariella, Gupta, Nalin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Early Phase Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715179/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.135
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