Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation

Cancer cells overexpress CD47 to subvert phagocytic elimination and evade immunogenic processing of cancer antigens. Moreover, CD47 overexpression inhibits the antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC) activities of therapeutic anticancer antibodies. Consequently, CD47-...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Hendriks, Mark A. J. M., Ploeg, Emily M., Koopmans, Iris, Britsch, Isabel, Ke, Xiurong, Samplonius, Douwe F., Helfrich, Wijnand
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714490/
https://ncbi.nlm.nih.gov/pubmed/33299654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1824323
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