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Blocking ‘don’t eat me’ signal of CD47-SIRPα in hematological malignancies, an in-depth review
Hematological malignancies express high levels of CD47 as a mechanism of immune evasion. CD47-SIRPα triggers a cascade of events that inhibit phagocytosis. Preclinical research supports several models of antibody-mediated blockade of CD47-SIRPα resulting in cell death signaling, phagocytosis of cell...
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| Publicado no: | Blood Rev |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6186508/ https://ncbi.nlm.nih.gov/pubmed/29709247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.blre.2018.04.005 |
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