MYC regulation of D2HGDH and L2HGDH influences the epigenome and epitranscriptome

Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that control the expression/activity of D2HGDH/L2HGDH are presumed to broadly influe...

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Detaylı Bibliyografya
Yayımlandı:Cell Chem Biol
Asıl Yazarlar: Qiu, ZhiJun, Lin, An-Ping, Jiang, Shoulei, Elkashef, Sara M., Myers, Jamie, Srikantan, Subramanya, Sasi, Binu, Cao, John Z., Godley, Lucy A., Rakheja, Dinesh, Lyu, Yingli, Zheng, Siyuan, Madesh, Muniswamy, Shiio, Yuzuru, Dahia, Patricia L. M., Aguiar, Ricardo C. T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714266/
https://ncbi.nlm.nih.gov/pubmed/32101699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.02.002
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