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MYC regulation of D2HGDH and L2HGDH influences the epigenome and epitranscriptome
Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that control the expression/activity of D2HGDH/L2HGDH are presumed to broadly influe...
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| Publicado en: | Cell Chem Biol |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7714266/ https://ncbi.nlm.nih.gov/pubmed/32101699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.02.002 |
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