MYC regulation of D2HGDH and L2HGDH influences the epigenome and epitranscriptome

Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that control the expression/activity of D2HGDH/L2HGDH are presumed to broadly influe...

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Publicado en:Cell Chem Biol
Autores principales: Qiu, ZhiJun, Lin, An-Ping, Jiang, Shoulei, Elkashef, Sara M., Myers, Jamie, Srikantan, Subramanya, Sasi, Binu, Cao, John Z., Godley, Lucy A., Rakheja, Dinesh, Lyu, Yingli, Zheng, Siyuan, Madesh, Muniswamy, Shiio, Yuzuru, Dahia, Patricia L. M., Aguiar, Ricardo C. T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714266/
https://ncbi.nlm.nih.gov/pubmed/32101699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.02.002
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