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Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression
Cyclic-AMP (cAMP) exerts suppressive effects in the innate and adaptive immune system. The PD-1/PD-L1 immune checkpoint down-regulates T-cell activity. Here, we examined if these two immunosuppressive nodes intersect. Using normal and malignant lymphocytes from humans, and the phosphodiesterase 4b (...
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| Veröffentlicht in: | Leukemia |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8187478/ https://ncbi.nlm.nih.gov/pubmed/33299141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-01105-0 |
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