Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression

Cyclic-AMP (cAMP) exerts suppressive effects in the innate and adaptive immune system. The PD-1/PD-L1 immune checkpoint down-regulates T-cell activity. Here, we examined if these two immunosuppressive nodes intersect. Using normal and malignant lymphocytes from humans, and the phosphodiesterase 4b (...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Leukemia
Päätekijät: Sasi, Binu, Ethiraj, Purushoth, Myers, Jamie, Lin, An-Ping, Jiang, Shoulei, Qiu, Zhijun, Holder, Kenneth N., Aguiar, Ricardo C. T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8187478/
https://ncbi.nlm.nih.gov/pubmed/33299141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-01105-0
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia