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MYC regulation of D2HGDH and L2HGDH influences the epigenome and epitranscriptome

Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that control the expression/activity of D2HGDH/L2HGDH are presumed to broadly influe...

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מידע ביבליוגרפי
הוצא לאור ב:	Cell Chem Biol
Main Authors:	Qiu, ZhiJun, Lin, An-Ping, Jiang, Shoulei, Elkashef, Sara M., Myers, Jamie, Srikantan, Subramanya, Sasi, Binu, Cao, John Z., Godley, Lucy A., Rakheja, Dinesh, Lyu, Yingli, Zheng, Siyuan, Madesh, Muniswamy, Shiio, Yuzuru, Dahia, Patricia L. M., Aguiar, Ricardo C. T.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2020
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7714266/ https://ncbi.nlm.nih.gov/pubmed/32101699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.02.002
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MYC regulation of D2HGDH and L2HGDH influences the epigenome and epitranscriptome

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