Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH Mutations in Glioblastoma

Isocitrate dehydrogenases (IDHs) catalyse oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). IDH1 functions in the cytosol and peroxisomes, whereas IDH2 and IDH3 are both localized in the mitochondria. Heterozygous somatic mutations in IDH1 occur at codon 132 in 70% of grade II–III g...

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Bibliografiske detaljer
Main Authors: Krell, Daniel, Assoku, Mawuelikem, Galloway, Malcolm, Mulholland, Paul, Tomlinson, Ian, Bardella, Chiara
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100313/
https://ncbi.nlm.nih.gov/pubmed/21625441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019868
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