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DeepPheno: Predicting single gene loss-of-function phenotypes using an ontology-aware hierarchical classifier

Predicting the phenotypes resulting from molecular perturbations is one of the key challenges in genetics. Both forward and reverse genetic screen are employed to identify the molecular mechanisms underlying phenotypes and disease, and these resulted in a large number of genotype–phenotype associati...

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Bibliografski detalji
Izdano u:PLoS Comput Biol
Glavni autori: Kulmanov, Maxat, Hoehndorf, Robert
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710064/
https://ncbi.nlm.nih.gov/pubmed/33206638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008453
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