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DeepPheno: Predicting single gene loss-of-function phenotypes using an ontology-aware hierarchical classifier

Predicting the phenotypes resulting from molecular perturbations is one of the key challenges in genetics. Both forward and reverse genetic screen are employed to identify the molecular mechanisms underlying phenotypes and disease, and these resulted in a large number of genotype–phenotype associati...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Kulmanov, Maxat, Hoehndorf, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710064/
https://ncbi.nlm.nih.gov/pubmed/33206638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008453
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