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Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks

While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts can be used to help generate diverse building block...

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書目詳細資料
發表在:ACS Catal
Main Authors: Wittmann, Bruce J., Knight, Anders M., Hofstra, Julie L., Reisman, Sarah E., Kan, S. B. Jennifer, Arnold, Frances H.
格式: Artigo
語言:Inglês
出版: 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709968/
https://ncbi.nlm.nih.gov/pubmed/33282460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.0c01888
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