Native Mass Spectrometry Reveals the Simultaneous Binding of Lipids and Zinc to Rhodopsin

Rhodopsin, a prototypical G-protein-coupled receptor, is responsible for scoptic vision at low-light levels. Although rhodopsin’s photoactivation cascade is well understood, it remains unclear how lipid and zinc binding to the receptor are coupled. Using native mass spectrometry, we developed a nove...

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Veröffentlicht in:Int J Mass Spectrom
Hauptverfasser: Norris, Carolanne E., Keener, James E., Perera, Suchithranga M. D. C., Weerasinghe, Nipuna, Fried, Steven D. E., Resager, William C., Rohrbough, James G., Brown, Michael F., Marty, Michael T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709953/
https://ncbi.nlm.nih.gov/pubmed/33281496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2020.116477
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