Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs

Membrane proteins play critical biochemical roles but remain challenging to study. Recently, native or nondenaturing mass spectrometry (MS) has made great strides in characterizing membrane protein interactions. However, conventional native MS relies on detergent micelles, which may disrupt natural...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Chem Soc
Egile Nagusiak: Keener, James E., Zambrano, Dane Evan, Zhang, Guozhi, Zak, Ciara K., Reid, Deseree J., Deodhar, Bhushan S., Pemberton, Jeanne E., Prell, James S., Marty, Michael T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475481/
https://ncbi.nlm.nih.gov/pubmed/30586296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11529
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