Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs

Membrane proteins play critical biochemical roles but remain challenging to study. Recently, native or nondenaturing mass spectrometry (MS) has made great strides in characterizing membrane protein interactions. However, conventional native MS relies on detergent micelles, which may disrupt natural...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Keener, James E., Zambrano, Dane Evan, Zhang, Guozhi, Zak, Ciara K., Reid, Deseree J., Deodhar, Bhushan S., Pemberton, Jeanne E., Prell, James S., Marty, Michael T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475481/
https://ncbi.nlm.nih.gov/pubmed/30586296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11529
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