Chemical additives enable native mass spectrometry measurement of membrane protein oligomeric state within intact nanodiscs

Membrane proteins play critical biochemical roles but remain challenging to study. Recently, native or nondenaturing mass spectrometry (MS) has made great strides in characterizing membrane protein interactions. However, conventional native MS relies on detergent micelles, which may disrupt natural...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Keener, James E., Zambrano, Dane Evan, Zhang, Guozhi, Zak, Ciara K., Reid, Deseree J., Deodhar, Bhushan S., Pemberton, Jeanne E., Prell, James S., Marty, Michael T.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475481/
https://ncbi.nlm.nih.gov/pubmed/30586296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b11529
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