Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma

Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic “driver” mutations in melanoma do not fit this UV signature. Here, we use genome sequencing to characterize mutations in yea...

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Udgivet i:Cell Rep
Main Authors: Laughery, Marian F., Brown, Alexander J., Bohm, Kaitlynne A., Sivapragasam, Smitha, Morris, Haley S., Tchmola, Mila, Washington, Angelica D., Mitchell, Debra, Mather, Stephen, Malc, Ewa P., Mieczkowski, Piotr A., Roberts, Steven A., Wyrick, John J.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709870/
https://ncbi.nlm.nih.gov/pubmed/33207206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108401
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