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Recurrent noncoding mutations in skin cancers: UV damage susceptibility or repair inhibition as primary driver?

Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically n...

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Vydáno v:Bioessays
Hlavní autoři: Roberts, Steven A., Brown, Alexander J., Wyrick, John J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571124/
https://ncbi.nlm.nih.gov/pubmed/30801747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201800152
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