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Recurrent noncoding mutations in skin cancers: UV damage susceptibility or repair inhibition as primary driver?

Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically n...

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Detalhes bibliográficos
Publicado no:Bioessays
Main Authors: Roberts, Steven A., Brown, Alexander J., Wyrick, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571124/
https://ncbi.nlm.nih.gov/pubmed/30801747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201800152
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