ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Recurrent mutations are frequently associated with transcription factor (TF) binding sites (TFBS) in melanoma, but the mechanism driving mutagenesis at TFBS is unclear. Here, we use a method called CPD-seq to map the distribution of UV-induced cyclobutane pyrimidine dimers (CPDs) across the human ge...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mao, Peng, Brown, Alexander J., Esaki, Shingo, Lockwood, Svetlana, Poon, Gregory M. K., Smerdon, Michael J., Roberts, Steven A., Wyrick, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035183/
https://ncbi.nlm.nih.gov/pubmed/29980679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05064-0
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