ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Recurrent mutations are frequently associated with transcription factor (TF) binding sites (TFBS) in melanoma, but the mechanism driving mutagenesis at TFBS is unclear. Here, we use a method called CPD-seq to map the distribution of UV-induced cyclobutane pyrimidine dimers (CPDs) across the human ge...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Mao, Peng, Brown, Alexander J., Esaki, Shingo, Lockwood, Svetlana, Poon, Gregory M. K., Smerdon, Michael J., Roberts, Steven A., Wyrick, John J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035183/
https://ncbi.nlm.nih.gov/pubmed/29980679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05064-0
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker