Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma

Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic “driver” mutations in melanoma do not fit this UV signature. Here, we use genome sequencing to characterize mutations in yea...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Laughery, Marian F., Brown, Alexander J., Bohm, Kaitlynne A., Sivapragasam, Smitha, Morris, Haley S., Tchmola, Mila, Washington, Angelica D., Mitchell, Debra, Mather, Stephen, Malc, Ewa P., Mieczkowski, Piotr A., Roberts, Steven A., Wyrick, John J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709870/
https://ncbi.nlm.nih.gov/pubmed/33207206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108401
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