Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

One hallmark of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the remarkable durability of silencing that can persist for months in preclinical species and humans. Here, we investigated the underlying biology supporting this extended duration of pharmacological activity. We found tha...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Brown, Christopher R, Gupta, Swati, Qin, June, Racie, Timothy, He, Guo, Lentini, Scott, Malone, Ryan, Yu, Mikyung, Matsuda, Shigeo, Shulga-Morskaya, Svetlana, Nair, Anil V, Theile, Christopher S, Schmidt, Karyn, Shahraz, Azar, Goel, Varun, Parmar, Rubina G, Zlatev, Ivan, Schlegel, Mark K, Nair, Jayaprakash K, Jayaraman, Muthusamy, Manoharan, Muthiah, Brown, Dennis, Maier, Martin A, Jadhav, Vasant
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2020
Предметы:
NAR Breakthrough Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708070/
https://ncbi.nlm.nih.gov/pubmed/32808038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa670
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