Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. Her...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708037/
https://ncbi.nlm.nih.gov/pubmed/33211885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1048
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