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Stimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid

ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates PC-lipids from the cytoplasmic to the extracellular leaflet. ABCB4 is an ATP-dependent transporter that reduces the harsh detergent effect of the bile salts by counteracting self-digestion. To do so, ABCB4 provides PC...

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書目詳細資料
發表在:J Lipid Res
Main Authors: Prescher, Martin, Smits, Sander H. J., Schmitt, Lutz
格式: Artigo
語言:Inglês
出版: The American Society for Biochemistry and Molecular Biology 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707170/
https://ncbi.nlm.nih.gov/pubmed/32917728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000889
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