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Stimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid
ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates PC-lipids from the cytoplasmic to the extracellular leaflet. ABCB4 is an ATP-dependent transporter that reduces the harsh detergent effect of the bile salts by counteracting self-digestion. To do so, ABCB4 provides PC...
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| Publicado no: | J Lipid Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7707170/ https://ncbi.nlm.nih.gov/pubmed/32917728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000889 |
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