Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesylated and geranylgeranylated proteins. Here, we in...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Lipid Res
Päätekijät: De Giorgi, Marco, Jarrett, Kelsey E., Burton, Jason C., Doerfler, Alexandria M., Hurley, Ayrea, Li, Ang, Hsu, Rachel H., Furgurson, Mia, Patel, Kalyani R., Han, Jun, Borchers, Christoph H., Lagor, William R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Biochemistry and Molecular Biology 2020
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707164/
https://ncbi.nlm.nih.gov/pubmed/33109681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120001006
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