Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

HMG-CoA reductase (Hmgcr) is the rate-limiting enzyme in the mevalonate pathway and is inhibited by statins. In addition to cholesterol, Hmgcr activity is also required for synthesizing nonsterol isoprenoids, such as dolichol, ubiquinone, and farnesylated and geranylgeranylated proteins. Here, we in...

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Foilsithe in:J Lipid Res
Main Authors: De Giorgi, Marco, Jarrett, Kelsey E., Burton, Jason C., Doerfler, Alexandria M., Hurley, Ayrea, Li, Ang, Hsu, Rachel H., Furgurson, Mia, Patel, Kalyani R., Han, Jun, Borchers, Christoph H., Lagor, William R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707164/
https://ncbi.nlm.nih.gov/pubmed/33109681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120001006
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