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Regulation of HMG-CoA reductase in mammals and yeast
HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of hypocholesterolemic drug therapy. HMGR activity is tightly regulated to ensure maintenance of lipid homeostasis, disruption of which...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3184313/ https://ncbi.nlm.nih.gov/pubmed/21801748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.plipres.2011.07.002 |
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