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Insig Regulates HMG-CoA Reductase by Controlling Enzyme Phosphorylation in Fission Yeast

Insig functions as a central regulator of cellular cholesterol homeostasis by controlling activity of HMG-CoA reductase (HMGR) in cholesterol synthesis. Insig both accelerates the degradation of HMGR and suppresses HMGR transcription through the SREBP-Scap pathway. The fission yeast Schizosaccharomy...

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Detalhes bibliográficos
Main Authors: Burg, John S., Powell, David W., Chai, Raymond, Hughes, Adam L., Link, Andrew J., Espenshade, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646361/
https://ncbi.nlm.nih.gov/pubmed/19041767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.09.004
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