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Insig Regulates HMG-CoA Reductase by Controlling Enzyme Phosphorylation in Fission Yeast
Insig functions as a central regulator of cellular cholesterol homeostasis by controlling activity of HMG-CoA reductase (HMGR) in cholesterol synthesis. Insig both accelerates the degradation of HMGR and suppresses HMGR transcription through the SREBP-Scap pathway. The fission yeast Schizosaccharomy...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646361/ https://ncbi.nlm.nih.gov/pubmed/19041767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.09.004 |
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