Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system

The endoplasmic reticulum (ER)–resident enzyme 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase catalyzes the rate-limiting step in sterol production and is the therapeutic target of statins. Understanding HMG-CoA reductase regulation has tremendous implications for atherosclerosis. HMG-CoA reduct...

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Bibliographic Details
Main Authors: Tsai, Yien Che, Leichner, Gil S., Pearce, Margaret M. P., Wilson, Gaye Lynn, Wojcikiewicz, Richard J. H., Roitelman, Joseph, Weissman, Allan M.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510011/
https://ncbi.nlm.nih.gov/pubmed/23087214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-08-0631
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