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Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
The endoplasmic reticulum (ER)–resident enzyme 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase catalyzes the rate-limiting step in sterol production and is the therapeutic target of statins. Understanding HMG-CoA reductase regulation has tremendous implications for atherosclerosis. HMG-CoA reduct...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510011/ https://ncbi.nlm.nih.gov/pubmed/23087214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-08-0631 |
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