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Dislocation of HMG-CoA Reductase and Insig-1, Two Polytopic Endoplasmic Reticulum Proteins, En Route to Proteasomal Degradation

The endoplasmic reticulum (ER) glycoprotein HMG-CoA reductase (HMGR) catalyzes the rate-limiting step in sterols biosynthesis. Mammalian HMGR is ubiquitinated and degraded by the proteasome when sterols accumulate in cells, representing the best example for metabolically controlled ER-associated deg...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Leichner, Gil S., Avner, Rachel, Harats, Dror, Roitelman, Joseph
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710830/
https://ncbi.nlm.nih.gov/pubmed/19458199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-09-0953
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