Metabolically Regulated Endoplasmic Reticulum-associated Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase: EVIDENCE FOR REQUIREMENT OF A GERANYLGERANYLATED PROTEIN

In mammalian cells, the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), which catalyzes the rate-limiting step in the mevalonate pathway, is ubiquitylated and degraded by the 26 S proteasome when mevalonate-derived metabolites accumulate, representing a case of metabolically regulated...

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Bibliographic Details
Main Authors: Leichner, Gil S., Avner, Rachel, Harats, Dror, Roitelman, Joseph
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173168/
https://ncbi.nlm.nih.gov/pubmed/21778231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.278036
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