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Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R), a key enzyme of sterol synthesis, is an integral membrane protein of the endoplasmic reticulum (ER). In both humans and yeast, HMG-R is degraded at or in the ER. The degradation of HMG-R is regulated as part of feedback control of the mevalonate path...

詳細記述

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書誌詳細
出版年:Mol Biol Cell
主要な著者: Hampton, R Y, Gardner, R G, Rine, J
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Cell Biology 1996
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC276048/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8970163/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.7.12.2029
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