Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R), a key enzyme of sterol synthesis, is an integral membrane protein of the endoplasmic reticulum (ER). In both humans and yeast, HMG-R is degraded at or in the ER. The degradation of HMG-R is regulated as part of feedback control of the mevalonate path...

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Vydáno v:Mol Biol Cell
Hlavní autoři: Hampton, R Y, Gardner, R G, Rine, J
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Cell Biology 1996
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC276048/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8970163/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.7.12.2029
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