Somatic editing of Ldlr with AAV-CRISPR is an efficient tool for atherosclerosis research

OBJECTIVE: Atherosclerosis studies in Ldlr knockout mice require breeding to homozygosity and congenic status on C57BL6/J background, a process that is both time and resource-intensive. We aimed to develop a new method for generating atherosclerosis through somatic deletion of Ldlr in livers of adul...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Jarrett, Kelsey E., Lee, Ciaran, De Giorgi, Marco, Hurley, Ayrea, Gillard, Baiba K., Doerfler, Alexandria M., Li, Ang, Pownall, Henry J., Bao, Gang, Lagor, William R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202188/
https://ncbi.nlm.nih.gov/pubmed/30026278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311221
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge