Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

Germline manipulation using CRISPR/Cas9 genome editing has dramatically accelerated the generation of new mouse models. Nonetheless, many metabolic disease models still depend upon laborious germline targeting, and are further complicated by the need to avoid developmental phenotypes. We sought to a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jarrett, Kelsey E., Lee, Ciaran M., Yeh, Yi-Hsien, Hsu, Rachel H., Gupta, Rajat, Zhang, Min, Rodriguez, Perla J., Lee, Chang Seok, Gillard, Baiba K., Bissig, Karl-Dimiter, Pownall, Henry J., Martin, James F., Bao, Gang, Lagor, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353616/
https://ncbi.nlm.nih.gov/pubmed/28300165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44624
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