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Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets
The potential of CRISPR–Cas9-based therapeutic genome editing is hampered by difficulties in the control of the in vivo activity of CRISPR–Cas9. To minimize any genotoxicity, precise activation of CRISPR–Cas9 in the target tissue is desirable. Here, we show that, by complexing magnetic nanoparticles...
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| Published in: | Nat Biomed Eng |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450418/ https://ncbi.nlm.nih.gov/pubmed/30944431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-018-0318-7 |
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