Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing

Despite advances in gene editing technologies, generation of tissue-specific knockout mice is time consuming. We used CRISPR/Cas9-mediated genome editing to disrupt genes in livers of adult mice in just a few months, which we refer to as somatic liver knockouts. In this system, Fah−/− mice are given...

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Библиографические подробности
Опубликовано в: :Gastroenterology
Главные авторы: Pankowicz, Francis P, Barzi, Mercedes, Kim, Kang Ho, Legras, Xavier, Martins, Celeste Santos, Wooton-Kee, Clavia Ruth, Lagor, William R., Marini, Juan C, Elsea, Sarah H, Bissig-Choisat, Beatrice, Moore, David D, Bissig, Karl-Dimiter
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420307/
https://ncbi.nlm.nih.gov/pubmed/30170115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.08.037
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