Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing

Despite advances in gene editing technologies, generation of tissue-specific knockout mice is time consuming. We used CRISPR/Cas9-mediated genome editing to disrupt genes in livers of adult mice in just a few months, which we refer to as somatic liver knockouts. In this system, Fah−/− mice are given...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Gastroenterology
Auteurs principaux: Pankowicz, Francis P, Barzi, Mercedes, Kim, Kang Ho, Legras, Xavier, Martins, Celeste Santos, Wooton-Kee, Clavia Ruth, Lagor, William R., Marini, Juan C, Elsea, Sarah H, Bissig-Choisat, Beatrice, Moore, David D, Bissig, Karl-Dimiter
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420307/
https://ncbi.nlm.nih.gov/pubmed/30170115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.08.037
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires