CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

The calcium-calmodulin–dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism. It is known to be activated by increases in intracellular Ca(2+), but the mechanisms by which it is inactivated are less clear. CaMKK2 inhibition protects against prosta...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Langendorf, Christopher G., O'Brien, Matthew T., Ngoei, Kevin R. W., McAloon, Luke M., Dhagat, Urmi, Hoque, Ashfaqul, Ling, Naomi X. Y., Dite, Toby A., Galic, Sandra, Loh, Kim, Parker, Michael W., Oakhill, Jonathan S., Kemp, Bruce E., Scott, John W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705300/
https://ncbi.nlm.nih.gov/pubmed/32913128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013756
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