AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965

Inhibition of the metabolic regulator AMP-activated protein kinase (AMPK) is increasingly being investigated for its therapeutic potential in diseases where AMPK hyperactivity results in poor prognoses, as in established cancers and neurodegeneration. However, AMPK-inhibitory tool compounds are larg...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Dite, Toby A., Langendorf, Christopher G., Hoque, Ashfaqul, Galic, Sandra, Rebello, Richard J., Ovens, Ashley J., Lindqvist, Lisa M., Ngoei, Kevin R. W., Ling, Naomi X. Y., Furic, Luc, Kemp, Bruce E., Scott, John W., Oakhill, Jonathan S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995511/
https://ncbi.nlm.nih.gov/pubmed/29695504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003547
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