Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

Mutations that reduce expression or give rise to a Thr85Ser (T85S) mutation of Ca(2+)-CaM-dependent protein kinase kinase-2 (CaMKK2) have been implicated in behavioural disorders such as anxiety, bipolar and schizophrenia in humans. Here we report that Thr85 is an autophosphorylation site that endow...

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Publicado en:Sci Rep
Main Authors: Scott, John W., Park, Elizabeth, Rodriguiz, Ramona M., Oakhill, Jonathan S., Issa, Samah M. A., O’Brien, Matthew T., Dite, Toby A., Langendorf, Christopher G., Wetsel, William C., Means, Anthony R., Kemp, Bruce E.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585769/
https://ncbi.nlm.nih.gov/pubmed/26395653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14436
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