Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

Mutations that reduce expression or give rise to a Thr85Ser (T85S) mutation of Ca(2+)-CaM-dependent protein kinase kinase-2 (CaMKK2) have been implicated in behavioural disorders such as anxiety, bipolar and schizophrenia in humans. Here we report that Thr85 is an autophosphorylation site that endow...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Scott, John W., Park, Elizabeth, Rodriguiz, Ramona M., Oakhill, Jonathan S., Issa, Samah M. A., O’Brien, Matthew T., Dite, Toby A., Langendorf, Christopher G., Wetsel, William C., Means, Anthony R., Kemp, Bruce E.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585769/
https://ncbi.nlm.nih.gov/pubmed/26395653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14436
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