Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway

Autoimmune uveitis (AU), being one of the sight-threatening ocular inflammatory disorders, has been widely regarded by ophthalmologists and immunologists as a great challenge. Apremilast, a phosphodiesterase-4 inhibitor (PDE4i), which was approved by the U.S. Food and Drug Administration (FDA) for t...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Chen, Yuxi, Li, Zhuang, Li, He, Su, Wenru, Xie, Yanyan, Pan, Yuan, Chen, Xiaoqing, Liang, Dan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705241/
https://ncbi.nlm.nih.gov/pubmed/33281814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.581673
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