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Theophylline Dosing and Pharmacokinetics for Renal Protection in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia
BACKGROUND: Theophylline, a non-selective adenosine receptor antagonist, improves renal perfusion in the setting of hypoxia-ischemia and may offer therapeutic benefit in neonates with hypoxic ischemic encephalopathy (HIE) undergoing hypothermia. We evaluated the pharmacokinetics and dose-exposure re...
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| Publicado no: | Pediatr Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7704857/ https://ncbi.nlm.nih.gov/pubmed/32919393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41390-020-01140-8 |
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