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Decreased Morphine Clearance in Neonates with Hypoxic Ischemic Encephalopathy Receiving Hypothermia

Morphine is commonly used in neonates with hypothermic ischemic encephalopathy (HIE) during therapeutic hypothermia to provide comfort and analgesia. However, pharmacokinetic data to support morphine dosing in this vulnerable population are lacking. A prospective, two-center, clinical pharmacokineti...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Pharmacol
Hauptverfasser: Frymoyer, Adam, Bonifacio, Sonia L., Drover, David R., Su, Felice, Wustoff, Courtney J, Van Meurs, Krisa P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240044/
https://ncbi.nlm.nih.gov/pubmed/27225747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.775
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