High-Dose Erythropoietin Population Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia

BACKGROUND: High-dose erythropoietin (Epo) is a promising neuroprotective treatment in neonates with hypoxic ischemic encephalopathy (HIE) receiving hypothermia. We evaluated the pharmacokinetics and dose-exposure relationships of high-dose Epo in this population to inform future dosing strategies....

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Udgivet i:Pediatr Res
Main Authors: Frymoyer, Adam, Juul, Sandra E., Massaro, An N., Bammler, Theo K, Wu, Yvonne W.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476365/
https://ncbi.nlm.nih.gov/pubmed/28099423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.15
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