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The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions

BACKGROUND: The present study aimed at examining the inhibitory effect of two atypical neuroleptics iloperidone and lurasidone on the main human cytochrome P450 (CYP) enzymes in pooled human liver microsomes and cDNA-expressed CYP enzymes (supersomes). METHODS: The activity of these enzymes was dete...

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Dettagli Bibliografici
Pubblicato in:Pharmacol Rep
Autori principali: Danek, Przemysław J., Wójcikowski, Jacek, Daniel, Władysława A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704495/
https://ncbi.nlm.nih.gov/pubmed/32279279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43440-020-00102-5
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